Garoppolo is expected to be sidelined a minimum of six weeks and possibly longer if surgery is needed, a source said, as Garoppolo continues to deal with a high ankle sprain that has bothered him since Week 2.
Garoppolo seemed to tweak his ankle earlier in the game but played through it before he was removed with 14:02 left to play. He limped to the locker room after going 11-of-16 for 84 yards with no touchdowns and an interception for a passer rating of 55.2.
Kittle’s foot injury came with 12:36 to play after he leaped to haul in a 25-yard pass from Mullens. Kittle made the play but came down awkwardly and hobbled to the sideline soon after.
San Francisco (4-4) plays the Green Bay Packers (5-2) on Thursday night.
Information from ESPN’s Nick Wagoner was used in this report.